A researcher from 吃瓜官网 has created a way to predict the risk of reproductive disorders in women with subclinical and overt hypothyroidism. This development allows us to assess the risk of reproductive disorders and carry out preventive measures in a timely manner.
Hypothyroidism is a disease caused by a long-term, persistent lack of thyroid hormones. It occurs in 2 to 4% of the adult population and is detected 5-10 times more often in women than in men. The disease is often accompanied by reproductive dysfunction and can lead to infertility. Sometimes the diagnosis of hypothyroidism is made late and in 10% of cases, hypothyroidism is not detected at all.
Evgenia Kudinova, Doctor of Medical Sciences, author of the study, and Associate Professor of the NSU Department of Obstetrics and Gynecology, explained that, 鈥淲omen seek medical help with infertility or disorders of the reproductive organs and one of the reasons may be hypothyroidism since it contributes to hormonal imbalance in the body鈥�.
While studying markers of tissue respiration in hypothyroidism, she noticed that the level of creatine phosphokinase (CPK), an enzyme that plays an important role in tissue metabolism, is interrelated with indicators of the state of the reproductive system. This observation was later confirmed by examining a number of patients suffering from reproductive dysfunction. It was also found that the risk group for the occurrence of ovulatory dysfunction includes women with an increase in not only CPK but blood homocysteine. This is a sulfur-containing amino acid, the oxidation of which in the plasma is accompanied by the accumulation of free oxygen-containing radicals that damage the vascular endothelium. These markers must be taken into account when assessing the high risk of ovulatory dysfunction, and, consequently, infertility.
Kudinova noted,
We confirmed that the level of the markers in the blood we studied can predict the risks of developing disorders in the reproductive function of the body in women with hypothyroidism. Timely detection of increased CPK and homocysteine is very important for the effectiveness of the applied treatment strategy.
She also emphasized that the diagnosis of markers is carried out through a routine analysis of venous blood and does not require complex additional equipment,
I think that in the near future we will continue our research taking into account the data obtained. The study of tissue respiration markers in women is very important when planning pregnancy, as well as in assisted reproductive technology programs. Normalizing these parameters allows us to move one step closer to solving the problems of infertility and eliminating its causes.
